Using transgenic mice to explore glial mechanisms of addiction

This project uses male and female conditional transgenic lines of mice to study glial cells implicated in addiction. Our transgene constructs are designed to add a fluorescent tag to differentiating oligodendrocytes and track the myelinating glial cells and formation of new myelin sheaths in vivo. This project focuses on breeding strategies and management of these lines of mice, as well as genotyping and related molecular techniques.